- Efficacy and Results
- Composition and Action Mechanism
- Indications
- Contraindications
- Dosage
- Side Effects
- Analogues
Unlike the numerous nutritional supplements for weight loss which the modern market is awash with and that are characterized by a questionable effect, doctors recommend Orlistat for weight loss – a real pharmaceutical drug that belongs to lipid-lowering agents. The active substance is orlistat, which blocks lipolytic enzymes in the digestive tract and reduces fat absorption.
It is prescribed for obesity complex therapy together with a low-calorie diet. It is considered to be one of the most effective in its field.
Efficacy and Results
The World Gastroenterology Organization classifies Orlistat weight loss pills (more precisely, its active ingredient orlistat) as moderately effective drugs for the treatment of obesity. Clinical studies were conducted, during which the following results were obtained:
- considerable weight loss in 75% of patients;
- over 12 weeks, patients lost up to 5% of their initial weight;
- when combining therapy with physical exercises and a low-calorie diet, higher results were noted – up to 10%.
Such therapy proved to be unexpectedly beneficial for the overall health of patients, especially hypertensive patients:
- blood pressure remained stable throughout the entire weight loss course;
- lipid metabolism indices significantly improved;
- cholesterol level in the blood and the content of lipoproteins decreased;
- development of type II diabetes was delayed.
Clinical trials of orlistat have made promising conclusions that Orlistat weight loss drug is one of the few that helps to fight excess weight without harm to health and even improving it. Unlike the numerous questionable nutritional supplements, it really directly affects the body’s lipid metabolism.
And if back in 1998 orlistat was patented in Switzerland under the name Xenical, then in Russia its first analogue was Orlistat, registered by the Slovenian company KRKA in 2009 and manufactured by it to this day.
Historical overview. Orlistat was first synthesized in 1985 by Swiss biochemists from the pharmaceutical company F. Hoffmann-La Roche Ltd.
Composition and Action Mechanism
How Orlistat weight loss medicine affects the body:
- orlistat (the main active ingredient of the drug) interacts with gastric lipases, inactivating their centers;
- blocked enzymes are no longer able to break down fats;
- solid lipid molecules due to their size cannot be absorbed into the blood stream;
- accordingly, fats are excreted unchanged;
- the amount of calories is reduced approximately by 30%;
- this leads to significant weight loss.
Along with these tasks, Orlistat weight loss drug provides additional bonuses, such as reduction of “bad” cholesterol and blood pressure.
With regular therapy, a conditioned reflex is formed: as soon as the patient consumes large amounts of fatty foods, diarrhea is guaranteed. So, he or she willy-nilly has to stick to a low-calorie menu.
With long-term therapy, weight loss occurs gradually, without crossing the boundaries of dietary norms. In 3 months, you can lose up to 8 kilos.
Since the capsules have the status of a full-fledged drug, it has medical indications and contraindications for use, which must be strictly adhered to.
Production Secrets. Orlistat is a drug that is obtained by biological means, naturally. For this, a certain strain of bacteria is used. The final product is a semi-manufactured product that contains orlistat and an auxiliary ingredient – microcellulose.
Indications
Doctors prescribe Orlistat’Slim weight loss pills (this is a milder drug that is different due to its sparing effect on the body) and regular Orlistat in the following cases:
- obesity, when the body mass index exceeds 30 kg/m?
- excess body weight, which is at least 27 kg/m?
At the same time, the drug is prescribed even to those patients who have a high risk of diabetes or cardiovascular diseases. They are not contraindications for Orlistat use, unlike some other conditions, which you must be aware of when choosing these weight loss capsules.
Legal status. Orlistat in Orlistat is currently the only medication officially approved for long-term obesity therapy. Initially, it was only available by prescription. This situation continues in Canada. In 2003, in New Zealand and Australia, it was moved to the category of non-prescription drugs. In the USA and EU countries, from 2006 to 2009, only those drugs were sold without prescription, in which the dosage of orlistat did not exceed 60 mg.
Contraindications
Harmful effects of Orlistat on the organs are diagnosed only in the case of an overdose of weight loss capsules or if there are contraindications:
- chronic malabsorption (the body loses nutrients);
- pregnancy;
- cholestasis (pathology of the gallbladder);
- lactation;
- age up to 18 years;
- individual intolerance to the drug.
This drug is not recommended for self-medication at home. It is prescribed by a doctor after a relevant examination during which the patient’s health status and the presence of these contraindications are ascertained. If they are identified, the underlying disease is treated first, and then the weight loss capsules are prescribed.
You need to know how to take Orlistat for weight loss so as not to harm your own body again. The drug is supplied not only with the instructions, but also with the directions from your physician.
Note. Orlistat does not affect concentration, therefore, you can safely drive a vehicle while taking it.
Dosage
The dosage and regimen of Orlistat are determined by the directions for use enclosed with the drug. You cannot violate the rules and recommendations specified in it if you want to lose weight quickly and without any harm to your health.
- Dosage: 1 capsule three times a day.
- Wash down with a small amount of water at room temperature.
- Take with food, as the effect of Orlistat begins only in the presence of enzymes in the digestive tract. The maximum allowable time interval is one hour after a meal.
- A prerequisite for therapy is the simultaneous intake of Orlistat with a small amount of fat. If they are absent in this meal, it is pointless to take the capsule.
- The weight loss course lasts until the desired result is achieved. The maximum period is 2 years.
If, for some reason, the meal was skipped, Orlistat weight loss capsules should not be taken. Increasing their dosage the next time is not recommended. This will not lead to any increase in the effect, but complications may arise.
Release form. 1 Orlistat capsule contains 225.6 mg of the semi-product, out of which 120 mg is orlistat. The substance is white or yellowish. Packaging – plastic blisters with cells and cardboard boxes with a certain number of capsules – 21/42/84 pieces.
Side Effects
Because